Forty-two cases of shigellosis in chidren were treated with sulfamethoxazole-trimethoprim(Septrin) from May 1970 to October 1972. 90% of the patients showed clinical improvement within 2 days and 40 of the 42 patients (95%) within 4 days.
On the 25 strains of shigellae, in-vitro sensitivity was tested aginst eleven antimicrobial agents. shigella flexneri was the most frequent organism(80%). The percentage of resistant strains to the eleven antimicrobial agents is as follows: Penicillin: 100%, Cloxacillin: 100%, Streptomycin: 92%, Chloramphenicol: 88%, Tetracycline: 88%, Kanamycin: 84%, Erythromycin: 40%, Neomycin: 32%, Ampocillin:20%, Gentamycin: 0%, SMX/TMP (Septrin): 0%.
All strains of shigellae tested were highly sensitive to SMX/TMP (Septrin) and Gentamycin.
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